While the central part of the book was focused on transferable skills such how to write and how to present which are relevant to anyone doing scientific research, the last three chapters of this book focus on skill that you need at a later stage of your career: how to lead a research group, how to get funded, and today subject, how to choose a research topic. Chapter 8 starts by re-analysing the purposes of scientific research and, from this, discusses why one should choose fundamental rather than applied research and how the research question differs across this divide. We briefly explain what Pasteur’s Quadrant is, and then we move to the core question: how do we choose our next topic to research? As usual, I first reviewed what was said about this, and I found very little; we report it in the book, but this left me quite unsatisfied. Thus, I decided to take a completely different approach. From 1990 to 2023, I selected 211 papers in which I was an author or co-author and in whi...